全文获取类型
收费全文 | 12738篇 |
免费 | 1184篇 |
国内免费 | 292篇 |
专业分类
耳鼻咽喉 | 48篇 |
儿科学 | 254篇 |
妇产科学 | 164篇 |
基础医学 | 563篇 |
口腔科学 | 85篇 |
临床医学 | 1338篇 |
内科学 | 1844篇 |
皮肤病学 | 202篇 |
神经病学 | 785篇 |
特种医学 | 303篇 |
外国民族医学 | 1篇 |
外科学 | 612篇 |
综合类 | 1417篇 |
现状与发展 | 1篇 |
预防医学 | 1736篇 |
眼科学 | 94篇 |
药学 | 3800篇 |
6篇 | |
中国医学 | 433篇 |
肿瘤学 | 528篇 |
出版年
2024年 | 39篇 |
2023年 | 430篇 |
2022年 | 752篇 |
2021年 | 957篇 |
2020年 | 832篇 |
2019年 | 731篇 |
2018年 | 682篇 |
2017年 | 582篇 |
2016年 | 569篇 |
2015年 | 566篇 |
2014年 | 1184篇 |
2013年 | 1061篇 |
2012年 | 926篇 |
2011年 | 968篇 |
2010年 | 731篇 |
2009年 | 576篇 |
2008年 | 529篇 |
2007年 | 441篇 |
2006年 | 323篇 |
2005年 | 280篇 |
2004年 | 189篇 |
2003年 | 162篇 |
2002年 | 116篇 |
2001年 | 85篇 |
2000年 | 69篇 |
1999年 | 67篇 |
1998年 | 50篇 |
1997年 | 49篇 |
1996年 | 32篇 |
1995年 | 42篇 |
1994年 | 26篇 |
1993年 | 29篇 |
1992年 | 24篇 |
1991年 | 11篇 |
1990年 | 14篇 |
1989年 | 17篇 |
1988年 | 10篇 |
1987年 | 6篇 |
1986年 | 15篇 |
1985年 | 12篇 |
1984年 | 13篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
11.
目的 探讨脑梗死后抑郁与负性生活事件的关系。方法 将脑梗死患者按是否受负性生活事件影响分为 A(n=75 )、B(n=73)两组。采用抑郁自评量表 (SDS)及 Hamilton抑郁量表筛查 ,对两组进行比较分析 ,并观察其治疗效果。结果 A、B两组脑梗死后抑郁的发生率分别为 5 6 %、38.4 % ,两者比较差异显著 (P<0 .0 5 ) ;百忧解可显著改善或治愈脑梗死后抑郁 ,总有效率 6 1.7%。结论 脑梗死后抑郁发生与负性生活事件相关。百忧解治疗有效 相似文献
12.
韩巧云 《实用医学影像杂志》2007,8(2):135-136
目的探讨欧乃影在临床应用中不良反应的发生和预防措施。方法观察2003年10月至2006年7月所作1000例增强扫描者静脉注射欧乃影0.2mL/kg(其量浓度(c)为0.5mol/L)后,不良反应发生的情况。结果1000例患者中,出现不良反应6例,其中,非过敏反应3例,轻度过敏反应3例,无中度及重度过敏反应。结论欧乃影在磁共振增强扫描中不良反应发生率低,临床应用安全。 相似文献
13.
M. Sibille N. Deigat V. Olagnier D. Vital Durand R. Levrat 《European journal of clinical pharmacology》1992,42(4):389-393
Summary All the clinical, laboratory and electrocardiographic adverse events detected during 24 Phase I studies in the same unit over a 5 y period are reported here. 430 healthy male volunteers were involved, corresponding to 5488 days of follow-up.The overall incidence of adverse events was 13.5%, with a significant difference between active drug (15.3%) and placebo (7.4%) treatments. There were 69 distinct types of adverse events. Headache was the most frequent symptom (2%). There were severe adverse events in 20 cases (0.36%), with an incidence of 20/430 per subject (4.6%). There were no deaths or life-threatening events.Although the main objective of Phase I studies is to determine the maximum dose tolerated, cause-effect relationships with adverse events are hard to establish, because of the frequency of adverse events with placebo, and because of the limited number of subjects included such studies. 相似文献
14.
We describe how adverse drug reactions (ADRs) can play an important role in pharmaceutical research and drug development. Not only do ADRs represent the risks and drawbacks associated with drugs but they can also be related to other knowledge available in pharmaceutical and medical research. We offer a model that can be used to systematically map the pathways through which ADRs can lead to innovative research. These pathways include chemical, therapeutic or pathophysiological steps that can be taken to arrive at new knowledge based on ADRs. We used the development of angiotensin-converting enzyme inhibitors, especially captopril, as a case study. The similarity between the ADR profiles of captopril and penicillamine was a starting point for further innovation. Historical analysis shows that in several instances research in the field of angiotensin-converting enzyme inhibitors has been triggered by ADRs. The model presented here might be applicable to other areas of innovative drug research. 相似文献
15.
16.
S. R. Hesslewood D. H. Keeling 《European journal of nuclear medicine and molecular imaging》1997,24(9):1179-1182
A prospective survey was performed in 17 nuclear medicine departments during 1996 in an attempt to provide reliable data on the prevalence of adverse reactions to radiopharmaceuticals. All adverse events following radiopharmaceutical administration were recorded, irrespective of the severity or likelihood of causality, and subsequently analysed using an algorithm developed by Silberstein et al., designed to establish a cause-effect relationship. A prevalence of 11 events per 105 administrations was obtained (95% confidence limits 3.3–19.2). No serious of life-threatening events were reported. This rate is slightly higher than that obtained in a larger scale study in the United States (2.3 events per 105 administrations, 95% confidence limits 1.2–3.4). The difference may be due to the decision to include or exclude vasovagal events from the analysis, the way in which the algorithm was used and the comparative size and time scale of the two studies. The prevalence of adverse reactions is approximately 1000-fold than less that occurring with iodinated contrast media and drugs. 相似文献
17.
18.
城市医疗救治体系在应对公共卫生事件中的管理实践与思考 总被引:1,自引:0,他引:1
医疗救治体系是公共卫生体系建设的重要组成部分 ,建立和完善医疗救治体系对于提高收治率、降低病死率 ,缓解公共卫生危机具有直接而关键的作用。该文总结回顾了上海在防治SARS期间医疗救治工作的组织与管理 ,简要介绍了上海构建突发公共卫生事件医疗救治体系的基本思路 相似文献
19.
The Effect of Antiepileptic Drugs on Cognition: Patient Perceived Cognitive Problems of Topiramate versus Levetiracetam in Clinical Practice 总被引:1,自引:0,他引:1
Hans-Peter R. Bootsma †Albert P. Aldenkamp Leonie Diepman Jacques Hulsman Danielle Lambrechts Loes Leenen Marian Majoie Ad Schellekens †Marc de Krom 《Epilepsia》2006,47(S2):24-27
Summary: Introduction: Neurocognitive complaints may interfere with long-term antiepileptic drug (AED) treatment and are an important issue in clinical practice. Most data about drug-induced cognitive problems are derived from highly controlled short-term clinical trials. We analyzed such cognitive complaints for the two most commonly used AEDs in a clinical setting using patient perceived problems as primary outcome measure.
Method: All patients of the epilepsy center Kempenhaeghe that received topiramate (TPM) or levetiracetam (LEV) from the introduction to mid 2004 were analyzed using a medical information system, an automated medical file. Patients were analyzed after 6, 12, and 18 months of treatment.
Results: Four hundred and two patients used either TPM (n = 260) or LEV (n = 142); 18 months retention showed a statistically significant difference, revealing 15% more patients that continued LEV compared to TPM: 18 months retention 46% for TPM and 61% for LEV [F (1.400) = 3.313, p = 0.043]. Neurocognitive complaints accounted for a significant number of drug discontinuations and especially the high frequency of neurocognitive complaints in the first period of TPM treatment appeared to be significant different from LEV [F(2,547) = 3.192, p = 0.042]. In the remaining patients, the difference in neurocognitive complaints was not statistically significant.
Conclusion: cognitive complaints are common in TPM treatment and frequently lead to drug withdrawal. The impact of LEV on cognitive function is only mild. This leads to a much higher (15%) drug discontinuation rate for TPM compared to LEV. 相似文献
Method: All patients of the epilepsy center Kempenhaeghe that received topiramate (TPM) or levetiracetam (LEV) from the introduction to mid 2004 were analyzed using a medical information system, an automated medical file. Patients were analyzed after 6, 12, and 18 months of treatment.
Results: Four hundred and two patients used either TPM (n = 260) or LEV (n = 142); 18 months retention showed a statistically significant difference, revealing 15% more patients that continued LEV compared to TPM: 18 months retention 46% for TPM and 61% for LEV [F (1.400) = 3.313, p = 0.043]. Neurocognitive complaints accounted for a significant number of drug discontinuations and especially the high frequency of neurocognitive complaints in the first period of TPM treatment appeared to be significant different from LEV [F(2,547) = 3.192, p = 0.042]. In the remaining patients, the difference in neurocognitive complaints was not statistically significant.
Conclusion: cognitive complaints are common in TPM treatment and frequently lead to drug withdrawal. The impact of LEV on cognitive function is only mild. This leads to a much higher (15%) drug discontinuation rate for TPM compared to LEV. 相似文献
20.
目的:探讨听性脑干反应(ABR)和40 Hz听觉相关电位(40Hz AERP)测试的相关性及对聋儿听力评估的重要性。方法:对401例6岁以下聋儿行ABR和40Hz AERP测试并比较。结果:ABR测试无反应者为589耳(73.4%),40 Hz AERP测试无反应者为311耳(19.4%),前者明显高于后者(P<0.01)。两种测试中有残余听力的耳数随阈值的升高,检出率亦升高,结论:ABR测试只反映高频听阈,无反应率高,而40 Hz AERP可显示低、中频的听阈,无反应率低。两种测试应同时进行,可全面了解聋儿的听力损失情况。同时因聋儿多为重度聋,更应及早选配助听器。 相似文献